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Evaluating the use of Low Dose Naltrexone During Pregnancy - A Retrospective Review of Pregnancy Outcomes.


Naltrexone is an opioid receptor antagonist which has been licensed since the 1980s at a dose of 50mg daily as an adjuvant treatment for opioid dependent drug users. Several newer uses for low dose naltrexone as an immune modifying treatment are known.  Low dose naltrexone has been used as part of Fertility treatment at NaPro Fertility Care since 2004.  It has improved PMS symptoms, fatigue as well as symptoms associated with endometriosis.  It is currently used as part of the treatment strategy for Low AMH (low ovarian reserve). More recently low dose naltrexone has been used throughout pregnancies. Our clinical experience indicates that there are no adverse effects to taking LDN in pregnancy and that it may be positively beneficial in reducing miscarriage and premature delivery.  This retrospective review compares pregnancy outcomes between those who were taking low dose naltrexone during pregnancy and those who were not.  We reviewed all patient charts from our clinic in 2012 and conducted a survey of the pregnant patients who first attended the clinic in 2010.  This paper analyses the responses to our survey and retrospective data review.


Medical Council Reg. No.  11986  

Date Feb 2014  

Age 46yrs Married with 4 children.

I am a General Practitioner with a special interest in infertility, miscarriage and  women ’s health . Currently I am the Director of two NaPro FertilityCare Clinics in the Beacon Mall, Dublin and The Galway Clinic, Co. Galway. I am currently president of The International Institute for Restorative Reproductive Medicine ( a doctors group that aims to publish and scientifically validate the work we do. We have published two papers on NaProTechnology, including a landmark publication in the Journal of the American Board of Family Medicine in Sept 2008.  I graduated in Medicine from the National University of Ireland, Galway in 1992. I am a member of both the Irish (MICGP) and Royal (MRCGP) College of General practitioners.  

I subsequently completed training as a FertilityCare Physician under the direction of Prof Thomas Hilgers, Omaha, NE, USA. I now specialise in the area of fertility evaluation and treatment. I am an active member of the American Academy of FertilityCare professionals (AAFCP) and I am a certified FertilityCare Medical Consultant (CFCMC) through the Academy.    

Currently 3 Doctors (including me) work through the Fertility Clinics in Dublin and Galway.  I have provided this treatment since 1998.  I am a member of the Irish Fertility Society. This group meets annually and membership is open to all professionals working in reproductive medicine in Ireland.